Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy
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چکیده
منابع مشابه
Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy.
The objective of this study was to evaluate the role of right ventricular hypertrophy on developed tension (F(dev)) and contractile reserve of rat papillary muscle by using a model of monocrotaline (Mct)-induced pulmonary hypertension. Calcium handling and the influence of bicarbonate (HCO(3)(-)) were also addressed with the use of two different buffers (HCO(3)(-) and HEPES). Wistar rats were i...
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The inotropic responsiveness to adrenergic stimulation is diminished in hypertension associated with left ventricular hypertrophy (LVH). This was shown in hypertrophied hearts from renal hypertensive rats (RHR) (two-kidney, one clip hypertension, Goldblatt) 6 weeks after renal artery clipping when compared to age-matched normotensive sham-operated controls (NR). The isoproterenol-stimulated ino...
متن کاملPreservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.
During ischemic heart diseases and when heart failure progresses depletion of myocardial energy stores occurs. D-Ribose (R) has been shown to improve cardiac function and energy status after ischemia. Folic acid (FA) is an essential cofactor in the formation of adenine nucleotides. Therefore, we assessed whether chronic R-FA administration during the development of hypertrophy resulted in an im...
متن کاملAcceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.
BACKGROUND Triggered arrhythmias arise from delayed afterdepolarizations (DADs), with Ca(2+) waves playing an important role in their formation. In ventricular hypertrophy, however, it remains unclear how Ca(2+) waves change their propagation features and affect arrhythmogenesis. We addressed this important issue in a rat model of hypertrophy. METHODS AND RESULTS Rats were given a subcutaneou...
متن کاملPreservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in the rat
During ischemic heart diseases and when heart failure progresses depletion of myocardial energy stores occurs. D-ribose (R) has been shown to improve cardiac function and energy status after ischemia. Folic acid (Fa) is an essential co-factor in the formation of adenine nucleotides. Therefore, we assessed whether chronic R/Fa administration during the development of hypertrophy resulted in an i...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2004
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00536.2002